Red blood cells (RBCs) ship oxygen to tissues and likewise contribute to hemostasis and thrombosis through platelet interactions that promote clot formation. In addition, RBC launch adenosine 5′-diphosphate (ADP) and extracellular vesicles, which promote procoagulant circumstances. It has also been observed that extended bleeding instances might be lowered in anemic patients with RBC transfusions, but the physiology was unknown. To gain a better understanding of the results of RBCs on hemostasis, researchers reconstituted human blood at various hematocrits and perfused it over immobilized collagen in a microfluidic chamber to mimic arterial wall sheer stress after vascular injury. Increasing hematocrit increased platelet thrombus formation below circulate circumstances, BloodVitals SPO2 but RBC membrane integrity was crucial for Blood Vitals RBCs to promote platelet aggregation. Mice with pancytopenia induced by irradiation formed small platelet-poor clots at vascular damage sites, wireless blood oxygen check however clot measurement increased 3- to 5-fold when mice were transfused with RBCs suggesting that RBCs improve hemostasis even within the close to absence of platelets. Further, outcomes recommend that prime sheer stress trigger RBCs to launch ADP and activate platelets and clot formation in patients with left ventricular help units. Additional studies are needed to raised perceive the role of RBCs in hemostasis. Cheryl L. Maier, Wilbur A. Lam